Dosing in preliminary and sequential treatment classes ought to be tailor-made to the person patient based mostly on the size, number and site of muscles concerned, severity of spasticity, the presence of native muscle weakness, the affected person's response to earlier treatment, and/or antagonistic event historical past with botulinum toxins. The least restrictive public tions of persisting bacilli in order to obtain durable treatment (pre well being interventions which might be efficient are used to achieve adher vent relapse) after completion of therapy; and (3) to stop ence, thereby balancing the rights of the patient and public safety. Metastatic disease ever (distant to liver, lung, lymph [ ] None nodes, peritoneum, brain, etc
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